top of page

Publications

Filter by Topic
Dural ectopic lymphatic structures accumulate during aging and exhibit dysregulation in neurodegenerative diseases

Fruitman Davidi A, Shirenova S, Michaelovich D, Benedetti G, Shtrasberg H, Shoval I, Hauschner H, Oz G, Vardy K, Hirsh T, Madar R, Stern E.A, Rosenmann H, Biragyn A and Okun E

2025

PNAS

CD8+ T cells exacerbate AD-like symptoms in mouse model of amyloidosis

Wang X, Campbell B, Bodogai M, McDevitt RA, Patrikeev A, Gusev F, Ragonnaud E, Kumaraswami KD, Shirenova S, Vardy K, Alameh MG, Weissman D, Ishikawa-Ankerhold H, Okun E, Rogaev E, Biragyn A.

2024

ScienceDirect

Unbiased analysis of spatial learning strategies in a modified Barnes maze using convolutional neural networks

Illouz T, Becker Ascher LA, Madar R, Okun E,

2024

Scientific Reports

Neural correlates of subjective cognitive decline in adults at high risk for Alzheimer’s disease

Ben-Ami L, Ravona-Springer R, Tsarfaty G, Raizman R, Shumacher A, Sharvit-Ginon I, Greenbaum L, B Bendlin B, Okun E, Heymann A, Schnaider Beeri M, Livny A.

2023

Frontiers

HCAR1‑Mediated l‑Lactate Signaling Suppresses Microglial Phagocytosis

Nicola R, Madar R and Okun E,

2022

SPRINGER NATURE Link

Sleeve Gastrectomy Reduces Glycemia but Does Not Affect Cognitive Impairment in Lean 5xFAD Mice

Samuel I, Ben Haroush, Schyr R, Arad Y, Attali T, Azulai S, Bergel M, Halfon A, Hefetz L, Hirsch T, Israeli H, Lax N, Nitzan K, Sender D, Sweetat S, Okun E, Rosenmann H and Ben-Zvi D.

2022

Frontiers

Integrative epigenomic and transcriptomic analyses reveal metabolic switching by intermittent fasting in brain

Gavin Yong-Quan Ng,Dominic Paul Lee Kok Sheng,Han-Gyu Bae,Sung Wook Kang,David Yang-Wei Fann,Jinsu Park, Joonki Kim, Asfa Alli-Shaik, Jeongmi Lee, Eunae Kim, Sunyoung Park, Jeung-Whan Han, Vardan Karamyan, Eitan Okun, Thameem Dheen, Manoor Prakash Hande, Raghu Vemuganti, Karthik Mallilankaraman, Lina H. K. Lim, Brian K. Kennedy, Grant R. Drummond, Christopher G. Sobey, Jayantha Gunaratne, Mark P. Mattson, Roger Sik-Yin Foo, Dong-Gyu Jo & Thiruma V. Arumugam,

2022

SPRINGER NATURE Link

COVID-19 Vaccination of Individuals with Down Syndrome-Data from the Trisomy 21 Research Society Survey on Safety, Efficacy, and Factors Associated with the Decision to Be Vaccinated

Hüls A, Feany PT, Zisman SI, Costa ACS, Dierssen M, Balogh R, Bargagna S, Baumer NT, Brandão AC, Carfi A, Chicoine BA, Ghosh S, Lakhanpaul M, Levin J, Lunsky Y, Manso C, Okun E ,Real de Asua D, Rebillat AS, Rohrer TR, Sgandura G, Valentini D, Sherman SL,

2022

MDPI

Physiology and pharmacology of amyloid precursor protein

Cho Y, Bae HG, Okun E, Arumugam TV, Jo DG,

2022

ScienceDirect

Immune Dysregulation and the Increased Risk of Complications and Mortality Following Respiratory Tract Infections in Adults With Down Syndrome

Illouz T, Biragyn A, Florencia Iulita M, Flores-Aguilar L, Dierssen M, De Toma I, Antonarakis S.E, Yu E, Herault Y, Potier M.C, Botté A, Roper R, Sredni B, London J, Mobley W, Strydom A and  Okun E. 

2021

Frontiers

Therapeutic B-cell depletion reverses progression of Alzheimer’s disease

Habashi M, Vutla S, Tripathi K, Senapati S, Chauhan PS, Haviv-Chesner A, Richman M, Mohand SA, Dumulon-Perreault V, Mulamreddy R, Okun E, Chill JH, Guérin B, Lubell WD, Rahimipour S

2021

Nature Communications

Adult Hippocampal Neurogenesis: One Lactate to Rule Them All

Nicola R and Okun E

2021

SPRINGER NATURE Link

Specific Susceptibility to COVID-19 in Adults with Down Syndrome

Illouz T, Biragyn A, Frenkel-Morgenstern M, Weissberg O, Gorohovski A, Merzon E, Green I,  Iulita F, Flores-Aguilar L, Dierssen Sotos M, De Toma H, Lifshitz H, Antonarakis S.E, Yu E, Herault Y, Potier M.C, Botté A, Roper R, Sredni B, Sarid R, London J

2021

SPRINGER NATURE Link

Induction of an effective anti-Amyloid-beta humoral response in aged mice

Illouz T, Madar R , Hirsh T , Biragyn A  and Okun E

2021

ScienceDirect

Maternal antibodies facilitate Amyloid-β clearance by activating Fc-receptor-Syk-mediated phagocytosis

Illouz T, Nicola R, Ben-Shuhan L, Madar R, Biragyn R and Okun E

2021

Communications Biology

Therapeutic B-cell depletion reverses progression of Alzheimer's disease

Kim K, Wang X, Ragonnaud E, Bodogai M,  Illouz T, DeLuca M,  McDevitt R.A,  Gusev F, Okun E, Rogaev E and Biragyn A

2021

Nature Communications

High‑Intensity Functional Training: Molecular Mechanisms and Benefits

B. Zeev T and Okun E

2021

SPRINGER NATURE Link

Mild physical activity does not improve spatial learning in a virtual environment

Okun E, B. Zeev T, Weiss I, Ashri S, Heled Y, Ketko I and Yanovich R

2020

Frontiers

The effects of High-Intensity Functional Training (HIFT) on spatial learning, visual pattern separation and attention span in adolescents

Okun E, Ben-Zeev T, Hirsh T, Weiss I and Gornstein M.

2020

Frontiers

A modified Barnes maze for an accurate assessment of spatial learning in mice

Illouz T, Madar R and Okun E

2020

ScienceDirect

Food and Age: It Takes Two to Degenerate

Nicola R and Okun E

2020

Frontiers

L-Lactate Promotes Adult Hippocampal Neurogenesis

Lev-Vachnish Y, Cadury S, Rotter-Maskowitz A, Feldman N, Roichman A, Illouz T, Varvak A, Nicola R, Madar R and Okun E

2019

Frontiers

The Toll Pathway in the Central Nervous System of Flies and Mammals

Shmueli A, Shalit T, Okun E and Shohat-Ophir G.

2018

SPRINGER NATURE Link

Deficiency of Toll-like receptors 2, 3 or 4 extends life expectancy in Huntington’s disease mice

Griffioen K, Mattson MP, Okun E

2018

Heliyon

Restoring microglial and astroglial homeostasis using DNA immunization in a Down Syndrome mouse model

Illouz T., Madar R., Biragyn A. and Okun E

2018

ScienceDirect

Extracellular DAMPs in Plants and Mammals: Immunity, Tissue Damage and Repair

De Lorenzo G, Ferrari S, Cervone F and Okun E. 

2018

Trends in Immunology

Dopamine receptors in the rat entopeduncular nucleus

Lavian H, Loewenstern Y, Madar R, Almog M, Bar-Gad I, Okun E and Korngreen A

2018

SPRINGER NATURE Link

Sirt6 alters adult hippocampal neurogenesis

Okun E, Marton D, Cohen D, Griffioen K, Kanfi Y, Illouz T, Madar R, Cohen HY

2017

PLOS One

Dopaminergic modulation of synaptic integration and firing patterns in the rat entopenduncular nucleus

Lavian H, Almog M, Madar R, Loewenstern Y, Bar-Gad I, Okun E, Korngreen A

2017

JNeurosci

Toll-like receptor 3 deficiency decreases epileptogenesis in pilocarpine model of SE-induced epilepsy in mice

Gross A, Benninger F ,Madar R, Illouz T, Griffioen K, Steiner I, Offen D and Okun E

2017

Wiley

The effect of nanoparticle size on the ability to cross the blood–brain barrier: an in vivo study

Betzer O, Shilo M, Opochinsky R, Barnoy E, Motiei M, Okun E, Yadid G and Popovtzer R

2017

Taylor & Francis Online

A protocol for quantitative analysis of murine and human amyloid-β1-40 and 1-42

Illouz T , Madar R, Griffioen K and Okun E

2017

ScienceDirect

Unbiased classification of spatial strategies in the Barnes maze

Illouz T , Madar R, Clague C , Griffioen K, Louzoun Y and Okun E

2016

Bioinformatics - Oxford Academic

Postnatal TLR2 activation impairs learning and memory in adulthood

Madar R, Rotter A, Ben-Asher HW, Mughal MR, Arumugam TV, Wood WH 3rd, Becker KG, Mattson MP, Okun E

2015

ScienceDirect

Unraveling cognitive traits using the Morris water maze unbiased strategy classification (MUST-C) algorithm

Illouz T, Madar R, Louzon Y, Griffioen KJ, Okun E

2015

ScienceDirect

DAMPs as mediators of sterile inflammation in aging-related pathologies

Feldman N, Rotter A, Okun E

2015

ScienceDirect

Cardiovascular Fitness and Cognitive Spatial Learning in Rodents and in Humans

Barak B, Feldman N and Okun E

2014

Gerontology - Oxford Academic

No ECSIT-stential evidence for a link with Alzheimer's disease yet

Illouz T and Okun E.

2014

Wiley

Toll-like receptors as developmental tools that regulate neurogenesis during development: an update

Barak B, Feldman N and Okun E

2014

Frontiers

bottom of page